Several studies have shown that women who consumed more than 10,000 IU a day in the first eight weeks of pregnancy have an increased risk of congenital disabilities. As mentioned earlier, congenital disabilities can arise either due to a deficiency or excess of vitamin A. The congenital abnormalities that occur due to deficiency of vitamin A have been listed below:
Kidney malfunction: This malfunctioning can lead to a disturbance in the electrolyte and mineral balance of the fetus.
Dysfunctional ureters: This is a condition where the ureters get blocked and lead to fetal urinary obstruction.
Cleft lip/palate: It is the splitting of a part of the face, mainly the area between the lip and nose. It can lead to speech disorders and difficulty in breathing.
Eye defects: Congenital night blindness affects vision in dim or low-light conditions.
Encephalocele: It is a condition where the neural tube does not properly close and leads to the brain sticking outside the skull.
Short/ long mandible: It is a condition where the infant has a smaller lower jaw than average or a more prominent lower jaw than average.
Overbite: It is a condition where the upper teeth align beyond the lower teeth, and underbite is a condition where the lower teeth align beyond the upper teeth.
Dental arch problems: One example of a dental arch problem is not enough space for all the teeth, leading to overcrowding. Teratogens are agents that can cause congenital disabilities or increase the chances of teratogenic effects. Chemical teratogens are supplements or vitamins ingested by the mother, inhaled from the environment. This can cause heart defects and spontaneous abortion. Most congenital disabilities arise due to taking supplements, and an excessive dose of vitamin A can cause teratogenic defects. In addition, it can cause neurodevelopmental and congenital nervous system defects.
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