Somatomedin C or Insulin-like growth factor 1 (IGF-1) IGF-1 is secreted by the liver. Growth Hormone is secreted from the pituitary gland and links to liver target cells, allowing themselves to produce IGF-1 and emit it. This hormone affects all cell types, which may be attributed to the presence of the IGF-1 receptor present on all cells. As it can connect to the Insulin Receptor, it displays insulin-like effects and produces triggers for development in the body. Though IGF-1 deficiencies are rare, cases have been reported and show its association with metabolic syndrome. A possible treatment is hormone replacement therapy IGF-1 is a part of the growth hormone, insulin-like growth factor (IGF)-I axis that regulates regulating linear growth in children. GH stimulates the release of IGF-I secretion and function and is associated with the nutritional status of the individual. Acid-labile subunit (ALS) was identified as a vital constituent in the development of the IGF/insulin-like growth factor binding protein-3 (IGFBP-3) (150-kDa) complex which is responsible for carrying the (almost (95%)) the circulation of IGF-1 and deciding its bioavailability to the cells. The ternary complex made up of IGF-I, ALS, IGFBP-3 performs the essential function of preventing the hypoglycemic effect of IGFs, prolonging their biological half-life, and avoiding cross-endothelial transport of insulin-growth factors.
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