Cholesterol is obtained from the diet and is also produced in the body, mainly in the liver. Food rich in dietary fats can increase cholesterol levels in the body. Some people have inherited causes that tend to keep a high level of cholesterol in their bodies. Lifestyle factors such as overweight, lack of physical exercise, and smoking can contribute to high levels of cholesterol as well. There are generally two kinds of cholesterol. The low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are the two categories of cholesterol based on the lipoprotein that carries cholesterol in the blood. While LDL carries cholesterol through your body and can deposit itself in the walls of arteries, HDL transports cholesterol to the liver. Having low HDL and high LDL is said to be harmful. This is so because LDL deposits will increase, and the removal of cholesterol by HDL will reduce. Aging can also be a factor in the risk of cholesterol. As age increases, the ability of the liver to remove LDL cholesterol reduces. High blood sugar can be a factor by increasing the levels of very-low-density lipoproteins (VLDL) and reducing HDL cholesterol.
Cardiovascular Effects of Cholesterol
High cholesterol circulation in the bloodstream can deposit on the walls of blood vessels. These accumulated deposits are called plaques. Plaques can narrow blood vessels and reduce blood flow and cause complications in the heart. Atherosclerosis is the condition of accumulation of cholesterol on the walls of arteries, causing the hardening of arteries.
The narrowing of heart arteries due to cholesterol deposition affects the supply of blood and can cause coronary heart diseases. When plaques break off and travel to small blood vessels, it can cause a complete block. Angina is the chest pain caused by the reduced flow of blood. Sometimes, plaques tear or rupture, causing a blood clot at the site. Such blocks can stop blood flow to the heart and cause heart attacks. Heart attacks can sometimes be fatal. Cholesterol plaques could accumulate in other areas such as legs and feet. Such blood vessel blockage can cause pain, for example, in the calves while walking. They are generally termed peripheral vascular diseases.
Stroke and Other Effects of Cholesterol
Stroke is a condition of a medical emergency, caused by the blockage of certain blood vessels in the brain. Cholesterol plaques can cause this blockage. When the blood supply to the brain is interrupted by plaques, certain brain regions do not receive sufficient oxygen that is required to function. This essentially causes the death of brain cells. Based on the region of the brain to which blood supply is blocked, various symptoms can occur. There could be difficulty in comprehending or producing speech during a stroke. Some may experience numbness, weakness, or paralysis of body parts. Headaches, blurring of vision, and loss of balance are other symptoms of stroke in the brain. Atherosclerosis caused by reduced blood flow due to cholesterol plaques can have other effects on the body. These include increased blood pressure and chronic kidney disease. High levels of cholesterol can cause an imbalance in bile juice. This may lead to the formation of crystals in the gallbladder, causing gallstones.
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