Following are some of the physiological functions of folate on human body:
1) The human body does not synthesize folate on its own and becomes required in the diet. This condition makes folate an essential nutrient that must get intake adequately from external sources.
2) Folates are crucial for chemical relations associated with cellular metabolism. It participates in methionine synthesis, ribonucleic acid (RNA) modification, DNA synthesis, DNA modification, and pyrimidine biosynthesis.
3) One salient folate function focuses on hematopoietic cells that promote red blood cell production. It also co-works with Vitamin C and B12 to break down and utilize proteins.
4) Folate creates new proteins to replace the utilized ones. A regular folate supply is required as the body does not store folic acid and is eliminated through urine.
5) Folate is primarily required during pregnancy and infancy to support cell growth periods. Reduced folate intake triggers neural tube defects and the risk of childhood asthma.
6) Reproductive field studies show that folate participates in spermatogenesis and oocyte maturation. In women, folic acid aids in implantation, placentation, gestation, and fetal development.
7) Meta-analysis ascertains that the immune response potential of folate can reduce cardiovascular risk by
4
%
4%. Tetrahydrofolate, a folate derivative, transports single carbon atom groups that assist in the biosynthesis and modification of multiple biological molecules.
8) Folate transits formyl, methylene, and a methyl group. Most folates stimulated processes to come under folate-mediated one-carbon metabolism.
Role of folate in immune system
Following are some of the physiological role of folate:
1) Folate has received particular attention regarding its role as an immune system-boosting vitamin. Multiple studies show that folate plays a salient role in immune cells such as B cells, T cells, and other antigen-presenting cells. Folate helps in immune response modulation and regulation.
2) Clinical findings show that consuming adequate folate levels can initiate T-helper-cell differentiation. It, in turn, triggers a cascade of the immune response against pathogens and other invading substances.
3) Folate must be an essential diet constituent as it balances lymphocyte activation. Folate deficiency significantly lowers T lymphocyte proliferation that eventually reduces the immune system capacity. Research shows that folate-deficient cells alter the immune system by decreasing the capacity of
CD
8
+
CD8+T cells (cytotoxic T lymphocytes also called CTLs) proliferation. These
CD
8
+
CD8+T cells are vital for immune defense against intracellular pathogens and also serve as tumor surveillance.
4) Folate status in the body controls the cell-mediated immunity that is devoid of antibodies. It maintains the blastogenic feedback mechanism of T lymphocytes to form morphologically modified lymphoblasts.
5) The folate effects on humoral immunity got more thoroughly researched in animals than humans. However, it does preferentially alter the thymus to control the immune response potential.
6) Deficiency of folate in humans shows undesirable changes in the polymorphonuclear cells. It reduces phagocytic and bactericidal capacities. Reduced folate intake brings down general immunity by exhibiting decreased resistance to infections.
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