Effects of marijuana:
The different chemical compounds in marijuana show different actions in humans. Delta-9-tetrahydrocannabinol (THC) makes marijuana consumers high. It helps them to relieve pain, nausea, vomiting, and reduce inflammation. It also acts as an antioxidant. Cannabidiol (CBD) helps treat seizures, reduce anxiety, and paranoia. This reduces the high state caused by THC. Marijuana can be taken into the body in different forms. When marijuana is smoked, the chemical components in marijuana reach the bloodstream rapidly through the lungs and go to the brain. When marijuana is consumed in food or beverages, it first reaches the digestive system. Therefore, the effects are less when consumed compared to inhaling or smoking. Once marijuana reaches the bloodstream, THC present in it alters the way the information is processed; for example, it leads to the wrong judgment of things. THC alters the memory function of the hippocampus, so the people who consume marijuana find difficulties in recalling things. THC induces the secretion of dopamine, which gives high feelings to marijuana consumers. Some people experience an increase in anxiety and depression, while others experience the reverse of that. Memory and concentration-related problems are observed in the developing brain of the babies whose mothers are regular marijuana consumers while pregnant. Marijuana smoking leads to burning in the mouth, cough, bronchitis, lung irritation, and even lung cancer in humans. When cells proliferate abnormally, and this leads to the growth of tumor cells. The studies have revealed that marijuana smoking has equal harm compared to tobacco smoking as well as causes lung cancer. Marijuana smoke contains two times the concentration of polyaromatic hydrocarbons that are carcinogenic compared to tobacco smoke. Marijuana is smoked without filters and with dense packing. Marijuana smokers tend to inhale more deeply and hold their breath for a longer time. This leads to the deposition of carcinogenic factors in the lower respiratory tract. Marijuana smokers absorb nearly five times more carbon monoxide than the tobacco cigarette of the same size. A recent study reveals that marijuana helps to treat nausea and vomiting in patients who undergo chemotherapy. It is also helpful in treating neuropathic pain. Marijuana smoking helps in the improvement of food intake in HIV patients. Some clinical trials show that cannabinoids and THC help reduce the growth rate of tumor cells in animal models. In humans, they do not show any control or cure other than pain relief during chemotherapy.
Marijuana and its role in the pharmaceutical sector:
Dronabinol (MarinolÂ®) is a drug approved by the FDA to treat nausea and vomiting in cancer patients. It is a capsule made of gelatin containing THC. Nabilone (CesametÂ®) is also used to treat nausea and vomiting in cancer patients. It is a synthetic cannabinoid that has functions similar to THC. Nabiximol is a drug that is yet to be studied in the U.S. Some people experience increased heart rate, low blood pressure, dizziness, and fainting while using these drugs. Some people also experience emotional imbalance and hallucinations while taking these drugs. The American Cancer Society insists on conducting more research on cannabinoids for cancer patients.
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