The bone cells are also termed as osteocytes. The bone cell which is responsible for the degradation or removal of a damaged or dead cell is done by osteoclasts. The osteoclasts are multinucleated cells, containing hundreds of thousands of lysosomes and mitochondria.
The osteoclasts break down the bone cell and degrade. At the place of dead bone cell, the new bone starts to form; this is known as bone formation. The reabsorption of bone tissues comes in the process of reabsorption of bone tissues. In this process, the osteoclasts break down the bone tissues and this releases the calcium, minerals, and other nutrients present in that particular bone cell. Therefore, all the minerals, calcium are released from the bone tissue cells to the bloodstream. The bone formation initiates with the condensation of mesenchymal cells; these mesenchymal cells form a cluster of cells which adhere to each other. This process further leads to bone generation or bone formation. The formation of bone occurs in a primary step called, osteogenesis or ossification. Further, there are two types of ossification processes that occur within the two different centers.
The word “osteo†means bone. Osteogenesis means the process of formation of bones. The formation of bone initiates when the progenitor cells start to from osteoblastic lines. It is further succeeded in three steps namely, differentiation of bone cells, the proliferation of bone cells, and maturation of osteoblastoma or matrix and mineralization. In other words, the process of ossification (or osteogenesis) is also referred to as bone remodeling. The process of bone remodeling takes place with the help of osteoblasts. In the process of Ossification or Osteogenesis production of new bones take place. The process of ossification initiates as soon as the fetus is three months old, which means during the process of embryogenesis, the fetus starts to develop bones when the fetus is only three months old and continues till the end of the adolescence period. The process of ossification is of two types namely, intramembranous and endochondral. Both of the ossification processes start with the mesenchymal tissues later over time it gets transformed into different bones.
There are two types of ossification processes taking place in the human body and are discussed below –
Intramembranous process of Ossification: During the process of Intramembranous ossification, the bone starts to develop directly from the mesenchymal connective tissue sheet. The bones which are formed during this process are compact and spongy. It gets directly developed from an undifferentiated sheet of connective tissues. Intramembranous ossification occurs mainly in the bones of the skull; moreover, they also occur in the region of cartilage, the cartilages are further replaced by bones. Therefore, Intramembranous ossification is essential for the formation of skull bone and facial bones. The examples of bone that are usually formed with the Intramembranous process of ossification include cranial bones, Clavicles, or collarbones, and several others.
Endochondral process of Ossification: During the process of endochondral ossification, there is a removal or replacement of the hyaline cartilage with the bone which means in the process of the Endochondral process of ossification the hyaline cartilage is replaced by bones. The process of Endochondral ossification initiates with the differentiation of mesoderm derived mesenchymal cells and chondrocytes. The chondrocytes divide at a very high rate in order to produce an extracellular matrix. The extracellular matrix forms the structural model for the bone. In this process, the osteo-progenitor cells from the intermediate cartilage before the replacement of bones. The endochondral process of ossification is responsible for the formation of long bones during the embryonic stage of development. During the process of endochondral ossification, the chondrocytes develop into the osteocytes. These cells are further destroyed to form the medullary cavity or they grow to form periosteum.
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