One, of this receptors, 5-HT2CÂ does not always lead to an increase of dopamine; constitutive activity of 5-HT2CÂ receptors in the mPFC contributes to the increase of dopamine when drug such as morphine, cocaine and other amphetamines are taken (Berg et al). Finally, 5-HTÂ 13Â has been associated with decreased amphetamine induced enhancement of responding to conditioned rewards but also caused increased dopamine release as well as amphetamine induced locomotion hyperactivity (Berg et al). Those are the key receptors that are involved in production and regulation of dopamine levels in the body.
Review of vast amount of literature indicates that there is no data to prove that dopamine regulates serotonin release and whether if such a relationship does exist or whether it is excitatory or inhibitory.
All the same there is no doubt that serotonin has both excitatory and inhibitory regulation of dopamine in the body (Berg et al). There is evidence that this relationship between serotonin and dopamine regulation and production exist since serotonin exerts itself by manipulating dopamine (Berg et al). Thus we can conclude that serotonin does indeed influence production and regulation of dopamine but not vice versa.
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