The development of the central nervous system (CNS) starts from the early stages when the embryo just two weeks old. The development of the hindbrain, midbrain, and forebrain starts. The brain and spinal cords are formed. Neurogenesis is the formation of a new neuron. In the body different cells have a different lifespan. The heart cells are as old as the person is. The skin cells are the newest. The mammalian cerebral cortex from few/no neurons after the birth of an individual. The dorsal surface of the CNS when thickens forms the neural tube. The tube surrounds a fluid-filled cavity. Its forward end develops into the hindbrain, forebrain, and midbrain. The rest becomes the spinal cord.
Proliferation- In proliferation, neuron recreation starts. The production of new cells/neurons occurs. Some cells become stem cells and others become glial or neuron for migration.
Migration- The neuron migrates to their respective places. The newly formed glia/neuron goes to their location. Some reach their destinations after adulthood. Chemical pathways guide the neuron for migration. The immunoglobulins (IgG) and chemokines guide the migrating neuron to the appropriate location. The interference to this chemical pathway by factors like alcohol can be easily caused. Neuron goes in multiple directions from the brain.
Differentiation- Neuron differentiates into different types of neurons. The formation of axons and dendrites occurs. The axons grow first and then the dendrites are formed according to the type of neuron. They can be multipolar, bipolar, or unipolar based on structural differences.
Myelination- Myelin sheath is an insulating sheath. It covers the axon of the neuron and protects it from damage. The faster conduction of signals down the axon is possible because of the myelin sheath. The neuroglial cells of CNS are called oligodendrocytes and neuroglial cells of PNS are called Schwann cells. These Schwann cells begin the formation of the myelin sheath during fetal development.
Synaptogenesis- The formation of the synapse is a structure that separates the two neurons and helps in chemical communication from the axon of one dendrite to the dendrite of the second neuron. It occurs throughout the lifetime but slows at a later age.
Growing axons reach their target, and they follow a gradient of chemicals. They are attracted to some chemicals and repelled by some chemicals. They form a synapse with the cells when they first reach their target. Some connection of the axon strengthens with the cells and some connections are eliminated. It depends on the input signals from the axon. The neural growth factors (NGF) like other factors promote survival and the activity of the neuron. Mental disorders arise by the combination of genetic factors and environmental factors. Both of these factors interact with the brain. The interaction creates the probability of may or may not be developing a mental disorder. Anything outside the brain affects the brain and has major impacts on the brain. The incredible brain development occurs in the first few years of the individual’s life. The environmental changes during this time of development cause the brain to develop in one way or another way. Some individuals are sensitive to the environment in which they live and some are much less sensitive. It is not known that individuals will have a more or less negative impact in their early stages. An optimal environment is necessary for the proper development of the brain. Research has found that the rats raised in the enriched environment develop thicker cortex, and dendrites have increased branching, and improved learning is seen. The new connection, which relates to learning is the gain and loss of spines. Fetal alcohol syndrome (FAS) is seen when the children are born if the mother drinks heavily during pregnancy.
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