The thyroid gland is composed of a huge number of follicles which were filled with a secretory substance called collide lined with a cuboidal epithelial cell which secretes into the follicles. Thyroglobulin is the major constituent of colloid. As soon as the colloidal secretion has arrived at the follicles, it must be captivated back over the follicle epithelium into the bloodstream before it can play its role in the body. The Hypothalamus gland secretes thyroid regulating hormone TRH, which acts on the pituitary gland to trigger it for the secretion of thyroid-stimulating hormone act on the thyroid gland and release the thyroid hormones.
Iodine enters the body through food and water in the form of iodide, and iodide is converted in the stomach simultaneously, thyroglobulin is synthesized in the endoplasmic reticulum active uptake of iodide is done by sodium iodine ion antiport ATPase pump, which is instigated by the pituitary hormone, thyrotropin as well as TSH. The process of oxidation is accomplished that tends to oxidize iodide by hydrogen peroxide to form iodine. This reaction is catalyzed by enzyme-containing heme, thyroid peroxidases (TPO). Process of active transport of iodine transversely towards the follicle cells, apical surface into the colloid filled with the lumen. Acceptance of thyroglobulin into the follicle’s lumen and the lining of iodinated tyrosine residue used for the coupling reaction to form T4 and T3. When 2 DIT residues are coupled, the coupling reaction is formed, and if DIT and MIT are coupled, then T3 is formed. This coupling reaction is catalyzed by the help of thyroid peroxidase under the impact of TSH droplets comprising of thyroid hormones inside the thyroglobulin molecules which is taken back into the follicle cells via the procedure named pinocytosis. It is a type of special form of endocytosis. The combination of colloid droplets with lysosome tends to cause hydrolysis of thyroglobulin and results in the release of T4 andT3.
Relationship between thyroid and tyrosine
There are two assemblies of hormones that are derivative of the amino acid named tyrosine. Thyroid hormones are fundamentally a “double” tyrosine with the serious incorporation of 3 or 4 iodine atoms. Catecholamines comprise epinephrine as well as norepinephrine, which are utilized as both hormones as well as neurotransmitters. This is because tyrosine is characterized as a building block for thyroid hormones, so complementing it might increase their levels too high. Thus, people who are consuming thyroid medicines or indicating an overactive thyroid should be cautious when complementing with tyrosine.
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