Kidney allograft rejection appears to be mediated by a number of risk factors. Chronic allograft rejection has the most number of risks factors involved and these encompass even the existence of previous acute rejection cases. Joosten et al (2005) highlights that among the most serious risk factor in chronic rejection is the existence of one or more acute rejection episodes in the past, though it is not obvious that an acute rejection episode in the past positively predicts the occurrence of a chronic episode in the future. If an acute rejection episode experiences some degree of function loss, the possibility of developing chronic rejection increases unlike when complete functionality of the kidney is achieved after the acute rejection episode.
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