A sarcomere is the basic unit of muscle structure which results in contraction. The boundary of a sarcomere is given by the Z line. These are the region where all thin filaments of a sarcomere bind and end. These filaments in the resting state of a muscle overlap each other to make the resting length of sarcomere about 2.2 . The length of sarcomere decreases when the muscles contract due to an increase in the overlap between the filaments. This increase in overlap is a result of the pulling of actin filaments by myosin filaments as a result of cross-bridge formation. Cross bridge formation is a process in which the actin filaments and myosin filaments bind to each other using their binding sites. It is the initial requirement for a muscle to contract. This is an ATP driven process. The ATP binds to the ATP binding site of myosin filament to drive this process.
Muscles can experience two types of contractions:
Isometric contraction refers to the type of contraction in which the length of the muscle remains unchanged.
Isotonic contraction- Muscles are the structures that are subjected to contraction frequently. In this type of contraction, the length of the muscle which is involved in contraction gets altered. It can be of two types:
Eccentric contraction- It is a type of isotonic contraction in which the length of muscle increases.
Concentric contraction- The type of isotonic contraction in which the length of muscle shortens.
Cross bridge formation generates tension in the muscle. The tension is a force exerted by the muscle on an object. In isotonic muscles, the muscle tension remains the same while muscle length changes. In isometric muscles, muscle length, and muscle tension are inter-related. The change in tension in isometric muscles is related to the length of the sarcomere of the overlapping region between the thick and the thin filaments. This is known as the length-tension relationship. It is observed in both skeletal and cardiac muscles.
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