Slimb plays a great role in the centiole reduplication and regulating their number, because mutations that occur in all sub-units affect this process. Even slight errors may affect the structure of cells which can result in cells with an insufficient or exigent number of centrosomes which, in its turn, it leads to the genomic instability (Brinkley 2001). The authors of the research hypothesized that that SCF Slimb ubiquitinates form of Plk4 on centrioles in order to control centriole duplication (Rogers et al. 2009). The aim of this study is to understand the mechanism of regulation that affects the centrosome duplication which will be a valuable funding for understanding of the cell behavior and preventing mechanisms of the cell mutations.
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