The mutations in CFTR happen due to the presence of nonsense alleles. X indicates the nonsense alleles and this type of mutation occurs in about 5 to 10% of CFTR mutations. It is important to note that there are many types of CFTR mutations. The X-linked recessive genes are passed down by parents to their children. Another type of mutation is G551D or class three that contains insignificant or no chloride channel hence the CFTR cannot allow the absorption of chloride ions. The other is the A455E mutation that has a partial ion channel function (Rowe, Miller & Sorscher, 2005).
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